Clinics & Centers

Laryngeal Precancerous Lesions Center

Pre-cancerous laryngeal lesions include vocal cord leukoplakia, hypertrophic laryngitis, and laryngeal papilloma, among which vocal cord leukoplakia is one of the common precancerous lesions in the larynx. However, its etiology and pathogenesis remain uncertain, and there is no acknowledged guideline about its treatment. Our center has conducted systematic and in-depth research on the etiology, diagnosis and treatment of vocal cord leukoplakia. We firstly discovered the possible correlation between Helicobacter pylori infection and vocal cord leukoplakia at home and abroad. Also, we firstly classified the vocal cord leukoplakia into three types: flat and smooth type, raised and smooth type, and rough type. We pointed out that the morphology of the vocal cord leukoplakia is closely related to the disease development and pathology, and thus its therapeutic method can be based on the morphology. The flat and smooth type should be treated non-surgically (cure rate of 80%), while operation should be performed on both raised and rough types. This helps us to reduce the surgical rate from 50~70% to 20% for the vocal cord leukoplakia. Regarding to the vocal cord leukoplakia, our center has a completed project from Shanghai Science and Technology Commission, a researching project from Healthcare Commission, and more than 10 SCI articles in the past 3 years. This is a leading center in China for the diagnosis and treatment of vocal cord leukoplakia.


Haitao Wu

Vice Principal:

Lei Cheng, Peijie He

Publications about the vocal cord leukoplakia:

1.Yue Yang , Jian Zhou , Peijie He, Haitao Wu .The Role of Keratin-8 and Keratin-18 Polymorphisms and Protein Levels in the Occurrence and Progression of  Vocal Leukoplakia. ORL. 2021;83(2):65-74.

2.Fang Y, Chen M, Yang Y, Chen J, Cheng L, He P, Wu H. The Variation of Peripheral Inflammatory Markers in Vocal Leukoplakia before and after Recurrence and Canceration. Dis Markers. 2020 Aug 1;2020:7241785. doi: 10.1155/2020/7241785.

3.Chen M, Fang Y, Yang Y, He P, Cheng L, Wu H. Helicobacter pylori is associated with poor prognosis of laryngeal precancerous lesion.  Auris Nasus Larynx. 2020 ;47(2):268-275.

4.Chen M, Fang Y, Cheng L, Wu H. Helicobacter pylori is associated with poor prognosis of laryngeal precancerous lesion. Auris Nasus Larynx. 2020 Apr;47(2):268-275

5.Fang Y, Chen M, He P, Cheng L, Chen J, Wu H. Elevated peripheral inflammatory markers related with the recurrence and canceration of vocal fold leukoplakia.Eur Arch Otorhinolaryngol. 2019;276(10):2857-2864.

6.Yue Yang, Jian Zhou, Haitao Wu.  Significance of cytokeratin-1 single-nucleotide polymorphism and protein level in susceptibility to vocal leukoplakia and laryngeal squamous cell carcinoma. ORL. 2019;81(2-3):121-129.

7.Chen M, Li C, Yang Y, Cheng L, Wu H. A morphological classification for vocal fold leukoplakia.Braz J Otorhinolaryngol. 2019;85(5):588-596.

8.Chen M, Chen J, Yang Y, Li CJ, Wu HT, Chen L.Conservative Treatment versus Surgery for Laryngeal Contact Granuloma: A Prospective Study. ORL J Otorhinolaryngol Relat Spec. 2018;80(5-6):307-316.

9.Chen M, Chen J, Yang Y, Cheng L, Wu HT. Possible association between Helicobacter pylori infection and vocal fold leukoplakia. Head Neck, 2018;40(7):1498-1507.

10.Li C, Zhang N, Wang S, Cheng L, Wu H, Chen J, Chen M, Shi F. A new classification of vocal fold leukoplakia by morphological appearance guiding the treatment.Acta Otolaryngol. 2018 ;138(6):584-589.

11.Min Chen, Lei Cheng, Chang-jiangLi, JianChen, Yi-laiShu,and Hai-taoWu. Nonsurgical Treatment for Vocal Fold Leukoplakia: An Analysis of 178 Cases. Biomed Res Int. 2017;2017:6958250.

12.Min Chen, Jian Chen, Lei Cheng, Haitao Wu.Recurrence of vocal fold leukoplakia after carbon dioxide laser therapy. Eur Arch Otorhinolaryngol. 2017 Sep;274(9):3429-3435.

13.Na Zhang, Lei Cheng, Min Chen, Jian Chen, Yue Yang, Ming Xie, Cai Li, XiaoLing Chen, Liang Zhou & Hai-Tao Wu.Relationship between Laryngoscopic and Pathological Characteristics of Vocal Cords Leukoplakia. Acta Otolaryngol. 2017;137(11):1199-1203.

14.陈敏,吴海涛,杨越, 等.声带白斑形态分型与选择性保守治疗预后相关性分析[J].临床耳鼻咽喉头颈外科杂志,2018,32(16):1260-1264.

15.陈敏,吴海涛. 声带白斑病因的研究进展.中国眼耳鼻喉科杂志.2016,6:442-445.