Chronic rhinosinusitis is a common disease in ENT, the incidence of which is near 10% in China. Traditionally, chronic rhinosinusitis is divided into chronic rhinosinusitis with polyps and chronic rhinosinusitis without polyps. In recent years, some scholars put forward the classification based on the state of eosinophils infiltration. At present, the treatment of chronic rhinosinusitis mainly relies on drugs and surgery, especially the application of endoscopic surgery, which has brought the treatment of chronic rhinosinusitis into a new era. However, it has been clinically found that some patients still have persistent nasal symptoms even after adequate medication and surgical treatment, which is called refractory rhinosinusitis. With the in-depth research on the pathogenesis of chronic rhinosinusitis, people have realized that chronic rhinosinusitis is a heterogeneous disease with mixed causes and pathogenic bases of different immune molecules. It is difficult to achieve personalized treatment for patients solely depending on polyps or the condition of eosinophils. With the advancement of the conception of precision treatment and the advent of type 2 inflammatory response biologics, we will explore phenotypes and endotypes of chronic rhinosinusitis, find reliable and sensitive biomarkers, formulate personalized drug treatment strategies and focuse on refining surgical plans of chronic rhinosinusitis.
The refractory rhinosinusitis medical center of ENT hospital, Fudan University was established in April 2021, by Professor Li Houyong as the person in charge, team members of 36 people, including 12 senior experts, 5 doctoral supervisors, 1 master’s supervisor, presiding over a number of National Natural Science Foundation and provincial research projects and training several post graduates annually. The center is the largest nasal treatment center in China, with an average annual number of more than 5000 rhinosinusitis surgeries, possessing the most advanced electrosurgical instruments，endoscopy system and image navigation system，conducting numerous researches on refractory chronic rhinosinusitis. The aim of the center is to improving the drug and surgical treatment strategies for refractory chronic rhinosinusitis and promoting the comprehensive ‘drug-surgery-biological agents’ treatment mode of refractory chronic rhinosinusitis through carrying out scientific and clinical research.