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Jiaxu Hong

MD, PhD

———— Personal Information ————

M.D., Ph.D.

OVERVIEW

Dr. Hong conducts basic and clinical research in the areas of ocular angiogenesis, corneal innervation, virus infection, inflammation, wound healing, and dry eye disease. He is the principle investigator of four federally funded research projects to explore the application of CRISPR/Cas9 to corneal disease and to investigate the efficiency of artificial intelligence diagnosis for common corneal diseases.

PUBLICATIONS

1. Di Yin, Sikai Ling, Dawei Wang , Yao Dai, Hao Jiang, Xujiao Zhou, Soren R. Paludan , Jiaxu Hong, Yujia Cai . Targeting herpes simplex virus with CRISPR–Cas9 cures herpetic stromal keratitis in mice. Nature Biotechnology. 2020. https://doi.org/10.1038/s41587-020-00781-8. Online ahead of print.

2. Zhou X,  Lv J,  Li G,  Qian T,  Jiang H,  Xu J,  Cheng Y,  Hong J. Rescue the retina after the ischemic injury by polymer-mediated intracellular superoxide dismutase delivery. 2020. https://doi.org/10.1016/j.biomaterials.2020.120600. Online ahead of print.

3. Ling S,  Yang S,  Hu X,  Yin D,  Dai Y,  Qian X,  Wang D,  Pan X,  Hong J,  Sun X,  Yang H,  Paludan SR,  Cai Y. Lentiviral delivery of co-packaged Cas9 mRNA and a Vegfa-targeting guide RNA prevents wet age-related macular degeneration in mice. Nat Biomed Eng . 2021 Jan 4. doi: 10.1038/s41551-020-00656-y. Online ahead of print.

4. Manafi N, Shokri F, Achberger K, Hirayama M, Mohammadi MH, Noorizadeh F, Hong J, Liebau S, Tsuji T, Quinn PMJ, Mashaghi A. Organoids and organ chips in ophthalmology. Ocul Surf. 2020;19:1-15.

5. Zhang C, Hu Z, Wang K, Yang L, Li Y, Schlüter H, Yang P, Hong J, Yu H. Lipidomic profiling of virus infection identifies mediators that resolve herpes simplex virus-induced corneal inflammatory lesions. The Analyst 2020, 145:3967-3976.

PROJECTS

2019-2022: Artificial Intelligence Diagnosis System for Corneal Disease (81970766) granted by National Natural Science Fund, China

2020-2022: Artificial Intelligence Diagnosis Core Device based on Slit-lamp (SHDC2020CR3052B) granted by Shanghai Municipal Health Commission


———— Specialty ————

Dr. Hong conducts basic and clinical research in the areas of ocular angiogenesis, corneal innervation, virus infection, inflammation, wound healing, and dry eye disease.